Lowe Lab

Single-molecule biophysics and quantitative imaging

London Centre for Nanotechnology (LCN)
Institute for Structural and Molecular Biology (ISMB)
University College London, Birkbeck College London, UK



We are an experimental biophysics lab comprising a team of physicists and biologists. We create and develop state-of-the-art quantitative imaging and measurement tools and use them to determine how biological machines and systems function. The major goal of our research is to identify the principles and mechanisms by which an ensemble of molecules or cells generate particular dynamic temporal or spatial patterns, and how complex functions emerge from that organisation.

For example, we have used single-molecule approaches to study the dynamics of proteins and protein complexes. We are developing super-resolution and single particle tracking approaches to characterise the mechanism and regulation of transport through the Nuclear Pore Complex. In doing so we are able to visualise the position and motion of cargos and the associated transport machinery during the translocation process.

Finally, we are developing sophisticated and quantitative live cell imaging approaches to understand larger scale functional and phenotypic changes in populations of cells

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Last updated 2016/02/11