Lowe Lab

Single-molecule biophysics and quantitative imaging

London Centre for Nanotechnology (LCN)
Institute for Structural and Molecular Biology (ISMB)
University College London, Birkbeck College London, UK


ORCiD orcid.org/0000-0002-0558-3597

Conformational transition of FGFR kinase activation revealed by site-specific unnatural amino acid reporter and single-molecule FRET.
Perdios L, Lowe AR*, Saladino G, Bunney TD, Thiyagarajan N, Alexandrov Y, Dunsby C, French PMW, Chin JW, Gervasio FL, Tate EW and Katan M
Sci. Rep. (2017), 7: 39841 PDF
*Corresponding author
Cyanobacteria use micro-optics to sense light direction.
Schuergers N, Lenn T, Kampmann R, Meissner M, Tiago Esteves T, Temerinac-Ott M, Korvink JG, Lowe AR, Mullineaux CW, Wilde A
eLife (2016), 4:e12620 PDF
(Press coverage: BBC, Wired, Telegraph, Atlantic, Science, Economist, Nature, Physics World)
Single-molecule imaging to characterise the transport mechanism of the Nuclear Pore Complex.
Jeremy G, Stevens J and Lowe AR*
Methods Mol. Biol. (2016), 1431:17-35 PDF
*Corresponding author
Mapping the topography of a protein energy landscape.
Hutton R, Wilkinson J, Faccin M, Sivertsson E, Pelizzola A, Lowe AR*, Bruscolini P, Itzhaki LS
J. Am. Chem. Soc. (2015) 137(46):14610–14625 PDF (Github resources: PyFolding)
*Corresponding author
Importin-β modulates the permeability of the Nuclear Pore Complex in a Ran-dependent manner.
Lowe AR*, Tang J, Yassif JM, Graf M, Huang, W, Groves J, Weis K and Liphardt J.
eLife (2015) 4:e04052 PDF (Github resources: NPC-localisation-tools)
*Corresponding author
Selectivity mechanism of the Nuclear Pore Complex characterized by single cargo tracking.
Lowe AR, Siegel JJ, Kalab P, Siu M, Weis K and Liphardt J.
Nature (2010) 467:600-3. PDF
(Press coverage: NCI, PhysOrg)
Rational re-design of the folding pathway of a modular protein.
Lowe AR and Itzhaki LS.
Proc. Nat. Acad. Sci. USA (2007) 104:2679-84. PDF
Biophysical characterisation of the small ankyrin repeat protein myotrophin.
Lowe AR and Itzhaki LS.
J. Mol. Biol. (2007) 365:1245-55. PDF
ATPase active site architecture in MCM and coupling of ATP hydrolysis.
Moreau MJ, McGeoch AT, Lowe AR*, Itzhaki LS and Bell SD
Mol. Cell. (2007) 28:304-314 PDF
*Joint first author

Reviews and Commentaries

From artificial antibodies to nanosprings: the biophysical properties of repeat proteins.
Lowe AR and Itzhaki LS.
Adv. Exp. Med. Biol. (2012) 747:153-166. PDF
A recurring theme in protein engineering: the design, stability and folding of repeat proteins.
Main ER, Lowe AR, Mochrie SG, Jackson SE and Regan L.
Curr. Op. Struct. Biol. (2005) 15:464-471 PDF
New developments in affinity chromatography with potential application in the production of biopharmaceuticals.
Lowe CR, Lowe AR and Gupta G.
J. Biochem. Biophys. (2001) 49:561-574. PDF